Capitalism Essay Example for Free

Capitalism Essay A society is capitalist if most production is carried on by employees working with means of production (equipment and materials) belonging to their employer, producing commodities which belong to the employer. (Employees: those whose services are treated as commodities. Labour is a commodity like any other, an article of trade Edmund Burke, Thoughts on Scarcity, 1795. Capitalism is an economic system in which the means of production are privately owned and operated for a private profit; decisions regarding supply, demand, price, distribution, and investments are made by private actors in the free market; profit is distributed to owners who invest in businesses, and wages are paid to workers employed by businesses and companies. This is what we mean by the system of Capitalism. Thinking about Capitalism, one directly is taken to the period of Marx and Engels where a distinction between Capitalist and Labour class was firstly and soundly made. Until then a capitalist continued to dominate the class hierarchy. Simple words suggest that a capitalist is a person in whose hands the entire power to production and the decision regarding the consumption vests. For ages capitalist class ruled the large part of the society. Even today, in several fields capitalists dominate other classes. Capitalism, as a deliberate economic system, developed incrementally from the 16th century in Europe, although proto-capitalist organizations existed in the ancient world, and early aspects of merchant capitalism flourished during the Late Middle Ages. Capitalism became dominant in the Western world following the demise of feudalism. Capitalism gradually spread throughout Europe, and in the 19th and 20th centuries, it provided the main means of industrialization throughout much of the world. Today the capitalist system is the worlds most dominant form of economic model. The term capitalist refers to an owner of capital rather than an economic system, but shows earlier recorded use than the term capitalism, dating back to the mid-seventeenth century. The Hollandische Mercurius uses it in 1633 and 1654 to refer to owners of capital. In French, Etienne Clavier referred to capitalistes in 1788, six years before its first recorded English usage by Arthur Young in his work Travels in France (1792). David Ricardo, in his Principles of Political Economy and Taxation (1817), referred to the capitalist many times. Karl Marx and Friedrich Engels, the great scholars of 18th century have continuously used the term ‘Bourgeois’ while talking about capitalist class. They raised points concerning the exploitation of Proletariats by the Bourgeois and asked the proletariats to fight for their rights. The Communist manifesto given by these scholars shows the distinction they have made between the two classes and the domination of powerful capitalist class in the society. Marx on Capitalism; How explain the possibility of Capitalism? Capital is money used to make money by buying commodities which are then to be sold to get an increased amount of money. How can money be used in this way? One answer is: by buying cheap and selling dear as prices fluctuate. This may explain how this or that individual makes money for a while, but since every gain made this way is someone elses loss, if those who gain that way now have an even chance of losing later, then it cannot explain the existence of a definite class of people who regularly make money. The explanation for the existence of such a class (capitalists) is that a limited set of people are in a position to buy a commodity which regularly yields an increase when they sell. This commodity is the service of the worker, which may produce commodities which exceed that service in exchange value (and only when when it does will the workers services be bought). The service of a worker is a commodity which has the special use of producing other commodities, which may have more exchange value than it has itself. There are other commodities (e. g. machines) which produce commodities, but (on the labour theory of value, which makes human labour the sole source of value) the exchange value contributed by a machine is simply a fraction of the cost in labour terms of making and working the machine. If over its whole working life it costs $3,000 and produces 3000 items, then it adds $1 to the value of each item. But the amount of labour a worker puts into what he produces over a lifetime may exceed the amount of labour needed to produce and maintain that worker. If some employer buys the workers services at their value i. e. for the equivalent of the labour needed to produce the worker then, since the workers product belongs to the employer, there will be an excess or surplus value, additional to the value of the wage, that the employer appropriates. Marx does not think that in the real world full value is always paid. But he conducts his argument on the hypothesis that full value is paid, for several reasons. First, he wants to make it clear that his analysis of capitalism does not rest on the assumptions that capitalists defraud the worker. Even if there were no cheating, capitalism could still exist. Second, he wants to show that even an idealized capitalism would be doomed to destruction (the argumentative strategy of proving the point for the hardest case: a fortiori it holds for other cases). Third, he wants to make it clear that it is in production itself, and not merely in the distribution of the product, that the capitalists profits originate; it is not accidental that most (though not all) capitals are used to finance production (not, e. g. , for buying non-human commodities and selling them unmodified). To argue that capitalism is a system of inequality and class conflict, Marx takes as his point of departure the idea that the dominant class, the bourgeoisie, controls capital, property, the means of production, and hence by extension all those (far more numerous than the bourgeoisie) who make up the laboring class (i. . , labor). Indeed, Marx sees an equivalence between capital, property, and the means of production, which are all concentrated in the bourgeoisie. More than this, Marx analyzes bourgeois power as aligned with fundamental forms of social organization and oppression: Hitherto, every form of society has been based . . . on the antagonism of oppressing and oppressed classes. . . . Society can no longer live under this bourgeoisie . . . its existence is no longer compatible with society (Marx, 2002, p. 209). Just as Marx links class power to political power, he links political power to industrial-economic power over the laboring classes. The bourgeoisies ability to control industry and economy had as its consequence bourgeois control of the political system. This dominance, according to Marxs logic, implies oppression of the majority of persons in society because capital will always seek to maximize its benefit. Marxs solution: revolution and dictatorship of labor, which Marx terms the proletariat. He does not deal with the result of such a dictatorship and seems to simply assume that the proletariat will exercise its own power in a just way. Capitalism and India; my viewpoint! (Socio-Economic) I am totally tuned in to the incentives, rewards, labour and profit motives of capitalism. It is not perfect. But it is historically absurd to deny that price and profit signals under capitalism have done a far better job of allocating scarce resources and sustaining long periods of economic growth than any other alternative. Communism proved itself to be a disaster wherever and in whatever name practiced. Remember the USSR? East Germany? Bulgaria? Romania? Albania? And the devastation of Cuba under Fidel Castro that his ageing brother Raul cannot fix? Socialism, too, has had its innings in the west as well as in the east, and failed. State-sponsored capitalism — once the hot East-Asian model — saw too much of the state, and relatively less of private capital, resulting in overarching ambitions, needlessly grandiose projects and poor long-term returns. Go to Dubai and see for yourself. And the mixed economy with the state occupying the ‘commanding heights’ meant one thing: too much of command with little or no height worth the name. So, if you were to closely observe the dirty, disordered canvas of economic progress during the 20th and 21st century, you should conclude that, for all its warts, capitalism has been the winner. It has sometimes caused pain; suffered from serious cycles; and often needed the clout of the state — such as we have seen from September 2008. It has also been quite resistant to sensible regulation. Even so, the basic institutions of capitalism have worked, not just in the US and the OECD (Organization for Economic Co-operation and development) nations, but also many developing countries, of which India is one. And worked better than alternative mechanisms. That brings me to India. As we move on to the second decade of the 21st century, here’s my core hypothesis: India is geared to have significantly more of capitalism than what we have had up to now. And the more the better. Let us begin with agriculture. Nowhere is there a more intensely capitalistic venture than farmers choosing the crops that they sow, water, weed, harvest and sell. Since the late 1960s, economists have run thousands of regressions called supply response functions, which quantitatively determine what best explains crop acreage and output over long periods. What are the results? From the turn of the 20th century right up to now, crops were planted according to expected prices and/or profits — surrogated by the price signals of the previous few years. Of course, other variables mattered such as rainfall, irrigation and fertiliser use. But the driving force was profits. Capitalism, therefore, defines 17 per cent of India’s GDP, namely agriculture. Now to services, which accounts for 55 per cent of GDP. If you deduct the share of government services, there is still some 40 per cent of GDP, much of it in the private sector. This is huge. And many of the activities are driven largely by profits. Whether it be mobile telephony, retail trade, restaurants, real estate, storage, hotels, road transport or finance, each service — big, medium, small or holes in the wall — rises, shrinks, falls, re-grows or disappears according to supply, demand, costs and pricing. Even earlier anti-market behemoths such as public sector banks and insurance companies have become more attuned to prices and profits than anyone could have imagined in the mid-1990s. Thus, 57 per cent of India’s GDP is tuned to capitalism. What about industry, which accounts for 28 per cent of GDP? Some two-thirds of it is purely private. That is another 18 per cent approximately. Moreover, most public sector undertakings are more price-and-profit oriented than ever before. So, hello capitalism! It accounts for at least three-quarters of our GDP. It may be higher still. But 75 per cent will do for now. Contrary to what the CPI, CPI(M) and some ‘don’t confuse me with facts’ professors tell you, India is awash with capitalism. Like China, you turn any corner, and you will meet someone who wants to start some business or the other: a photocopying shop, an STD booth, a local agency for Dabur, Godrej or Hindustan Unilever, automobile spare parts — the list is endless. The state must allow these millions of capitalists to thrive. By creating essential infrastructure such as roads and power; by fostering basic facilities for education and training; by encouraging entrepreneurship through clean governance; and by creating level playing fields. These are tough tasks, but if the state succeeds in some fair measure, you can be sure that India’s millions of capitalists will make 9 per cent GDP growth look silly. We have it in us. In spades. Conclusion Over the centuries, capitalism and capitalist class has changed with time. It is worth adding that the impact of Capitalism on Society, economy, polity is huge. This has made it a multi-disciplinary subject of discussion. Domination of other classes of a society by a particular section of the society can never be justified and hence capitalism has been largely criticized by various scholars all over the world. The work of Marx on Capitalism is praiseworthy and is still followed today when issues regarding capitalism arise.

Marketing Analysis of Netflix

Marketing Analysis of Netflix Netflix is an online company with corporate headquarters in Los Gatos, California. Netflix was founded by Hastings who is also the CEO of the company. Netflixs key business is online rental services in the software industry. Netflixs software business services span various software products and services. Among these are DVD movies and several other software products. Despite disappointing results on its performance at the beginning, the innovative entrepreneur continued to tailor the company while identifying and exploiting new opportunities that presented themselves. That was when the company designed and developed a website that saw it host millions of subscribers making it rake in huge profits. That was in 2006. Netflix was founded at a time when the video industry was largely populated by small retail outlets which were characterized by long product delivery time. The market was dominated by the then giant Blockbuster Inc. Blockbuster had no real marketing strategy and customer royalty was based on impulsive buying. It enjoyed booming sales with almost 100 percent success when Netflix joined the market. Upon its entry into the market in 1997, Netflix realized that the market that was dominated by the brick and motor marketing methods. The launch of this company was at the time of the beginning of internet retailing. Online selling was gaining an upper hand to brick and motor methods. This compelled Netflixs to launch its own website in 1998 that specialized in the use of cross platform technologies in service delivery. At this time, different pricing models were tested to increase sales volume. Netflix was also adept at countering new entrants and developments in the market. One of this was the development of a video provision services on line. Porters Generic Strategy According to Porter (1974), successful business organizations incorporate one or more of the generic strategy options to propel it to success. Among these strategies are cost leadership, focus, and group differentiation. A critical analysis and evaluation of the cases study reveals that Netflix had to various extents incorporated these strategies in its business pursuits with each generic strategy contributing to the success or failure of the company in its pursuits. Netflix emphasized on the focus strategy with the other strategies playing a minor role in the firms pursuits. The differentiation strategy is where a company concentrates its efforts in developing a single product then invests in identifying and incorporating unique attributes that meet customer needs (Porter, 1974). Porter (1975) asserts that by adding value to a product and creating uniqueness in product to attract customers, customers are likely to purchase the product at a higher price. That was the case with Netflix. Netflix original move into the market targeted the renting of videos in the movie industry. That strategy could be achieved by the use of recently developed and upcoming internet marketing technology which other companies had not incorporated in their business pursuits. The case study reveals that Netflixs newly launched website integrated a search engine that enabled each customer to search and access products of ones choice. Netflixs management showed such talent and ingenuity in marketing their products by employing already available and established supply chain infrastr ucture and technology. One of the infrastructure tools included the USs postal services. The firm incurred slight expenses in delivering the DVDs to the customers as they were light in weight. In creating value and uniqueness to its products using the group differentiation strategy, Netflix endeavored to characterize its products with value, user friendliness and convenience, and unique selections. That was evident when Hastings coined a term for their customers that Amazon used to refer to its customers, eBay. According to Porter (1975), a company that invests in this approach should be led by a well skilled and dedicated team. That was the case with Netflix. Netflixs management was led by Hastings, an entrepreneur at heart. In addition to that, Porter affirms that a company organized around pursuing excellence and aiming at gaining a greater advantage in the market should have a good reputation should revolve around high product quality and innovation. The case with Netflix is outstanding here. Netflix did not only focus on DVD sales, they had other serious considerations in product innovation. Among these were a focus on video-on-demand and alternatives to VOD. Porter (1974) argues that a company may not necessarily integrate all the generic characteristics depending on the nature of its business. An analysis of the case study indicates that Netflix did not pay much attention to cost leadership. Some of the pricing models did not work for Netflix. One such model involved a situation where the firm spent several thousands of dollars in adverts only to gain a paltry income from such an endeavor. Netflix at times charged high rental fees for their online videos which at times drove its customers away. However, technology seems to have paced Netflix at an upper hand compared to other companies involved I the same business pursuits. However to a large extent, Netflix incorporated the generic aspect of focus strategy. The focus strategy is where a firm concentrates on one firm and later on attempts to manipulate product prices to achieve an advantage over competitors (Porter, 1975). Netflix did not succeed with this strategy to a desirable extent but seems to have lost some customers due to that. Porters Five Forces Netflix entered a market that Porter (1974) affirms is driven by five forces. These include the bargaining power of customers, threat of new entrants, bargaining power of buyers, threat of substitute products, and rivalry among competing firms. At Netflix, the bargaining buyer of customers was realized when despite intensive marketing activities, the firm earned paltry sums far below their target. Instead of earning the company more customers, thus increasing the revenue, the company was facing a loss. Customers had driven sense into the companys executives that they could determine a companys profitability and the model they use in pricing their products. This pricing element was evident when some customers felt dissatisfied by the pricing system compelling Netflix to rethink and introduce a new pricing mechanism. Netflix could counter new entrants by its relentless pursuits to adopt new technologies and integrate them to the service sit was offering. That was the case when it entered the field of video-on-demand. Despite the huge investments it had made, Netflix did not realize quick returns as there were no technologies in the form of hardware platforms to support such services. Netflix is noted to have lost a chunk of revenue in advertising these service customers were not willing to pay for. The case study however reveals that later innovations saw Netflix succeed in this field. One other case was the entry of VOD services and the fierce completion Netflix had to fight off before they could get a foothold in this widely dominated market by Netflix. Netflix swung into action by exploiting new technology platforms that were not characterized by her competitors in gaining a firm foothold. Another force experience in this industry was the bargaining power of buyers. As discussed above, Netflix had to succumb to buyers buying behavior as in some instances; new innovations could not be priced as per Netflixs dreams. That was the case with investments and intense marketing campaigns conducted by Netflix for the newly launched services, VOD. Porter (1975) asserts that companies can endeavor to enter a market by offering substitute products that may serve the needs of current products offered in the market. The case with Netflix is a striking one. The case study reveals that substitute products were too below bar in competing with those offered by Netflix and the company was now enjoying an undisrupted share of the market. Netflix carefully blended these generic forces to its advantage. Rivalry among competing firms saw Netflix to be a runaway case. Arguments demonstrate how competitors went to the extent of accusing Netflix of infringing upon copy right laws in offering these videos online. This line of attack was shaken off by Netflixs executives who argued that Netflix was offering these services just like any retail outlet could buy and sell a product, except Netflix was using the new internet technology that these other firms had not put to full use. Value Chain Netflixs management was keen at exploiting information technology in incorporating value chain activities in its service. A striking example was when the companys turnaround time for product deliveries was drastically enhanced by the use of appropriate technology. Each customer who opted to stay or leave the company could be requested to leave an answered questionnaire about their decisions. These could be used to identify the weaknesses inherent in the system and determine new methods of fulfilling customer needs and wants. One such revelation was identified with the companys ever changing rental fees. Other value chain addition activities spanned the infrastructure the company was using and its implementation of new technologies to enhance value for its customers. Netflixs system product acquisition was also automated, with automated searches using an integrated search engine. Implementation of Information Technology in Netflix To stay afloat in the already large market and maintain the customer base, Netflix will have to implement an IT infrastructure that could offer reliable support for its business transactions (Smith, Short, 2001). One of these could be a data mining application. The data mining application could be integrated in the organizations information system to assists in decision making. Netflix is a highly customer focused organization. Data mining could help enhance communication, help the company compare its prices with other companies evaluate customer satisfaction, evaluate supplier relationships, enhance staff skills, and provide an overview of company progress and performance. On the other hand decision support system could be incorporated into the company to help improve decision making from the companys data warehouse, provide real time sales compressions, and model decision making context (Shermis, Stemmer, Berger, Anderson, 1991). The outputs from this system could significantly depend on the inputs from the companys data warehouse and the decisions made could reflect the actual potion of the company. In addition to that, a customer relationships management should be incorporated as it helps the management to sustain its old and new customers, meet customer needs, and establish a good working relationship with other companies and customers. According to Silverman (1993), a supply chain management system if well incorporated into this company could help create competitive advantage for the firm by enabling it to optimize all factors relevant to customer satisfaction and company benefits. This system could help the company identify key factors central to its success and enable management optimize all aspects of controls in its marketing strategies and supply and acquisition logistics (Smith, Short, 2001). Recommendations Based on the above discussion, Netflix should continuously adapt to changing technological dynamism and new market opportunities in reaching various markets. Netflixs management should hire experts on cross culture management to ensure a cross culture component is incorporated in its pursuits. This could be the case since newer opportunities lie outside Netflixs current market that is characterized by a fairly uniform culture. In addition to that, the firm should incorporate user friendly software products that are cross platform and compatible with other software products to enhance usability. To maintain a large market share, the company should always incorporate faire business practices in its pursuits. In addition to that, Netflix should endeavor to develop software that can bar piracies on its products in addition to patenting its products. The company should invest in software technologies that bar any could be illegal downloading of files or unauthorized access or copying of i ts products. That could bar illegal usage of its video products since it denies the company legitimate profits that could accrue from those sales. The company should continuously evaluate the role played by information technology in propelling it to its position, the ever changing trends in the industry I terms of provision of services and other related services. It should continuously revise its plans to make them current and relevant to the identified changes and endeavor to incorporate new technologies in its pursuits.

Muscarinic Acetylcholine Receptors In The Pig Urinary Bladder Biology Essay

Muscarinic Acetylcholine Receptors In The Pig Urinary Bladder Biology Essay Background and purpose. This investigation sought to identify the principal muscarinic receptor subtype associated with contraction of the pig bladder. Additionally, comparisons of muscarinic receptor expression in the pig bladder and caudate nucleus were conducted. Experimental approach. Contractility of isolated strips of pig bladder was assessed using isotonic tension recordings in an organ bath. Radioligand binding to particulate preparations from pig caudate nucleus and bladder detrusor was assessed using [3H]-quinuclidinylbenzilate. Key results. The results obtained from the contractile response experiment showed that the best antagonists for pig bladder contractions were methoctramine, pirnezepine and oxybutynin, this was according to the pEC50 data. These results led to the identification of the presence of M1 and M3 receptor subtypes in the bladder. Whereas M1 and M2 receptor subtypes were found to occur in the brain. Pirenzepine exhibited the smallest Rmax value, and was therefore the most successful antagonist. Whereas 4-DAMP had the largest Rmax value, identifying this as the worst antagonist. Conclusions and Implications. It is clear that M3 muscarinic receptors are found in the bladder, but are absent in the brain. This is made more certain as 4-DAMP showed fairly low affinity for muscarinic receptors in the bladder, but its affinity was higher than that recorded in the brain which is known to contain a low amount of M3 receptors. 4-DAMP also has the highest affinity recorded in the brain, due to binding at the M1 muscarinic receptor. Introduction There are five distinct types of muscarinic receptors (M1,M2,M3,M4,M5), all of which belong to the same family of G-protein-coupled receptors. M1 receptors are found mainly in the cortex and hippocampus of the brain, but also on the CNS and peripheral neurons. These receptors are excitatory, this excitation is produced by a decrease in potassium ions which causes membrane depolarization. M2 receptors exert inhibitory effects; they are present in the heart and so are of little importance in this experiment. M3 receptors reside in smooth muscle. These receptors are excitatory and produce vasodilatation and bronchodilatation, via an increase in intracellular calcium levels. As this experiment includes analysis on the effects of muscarinic antagonists on muscarinic receptors in the brain and bladder, it is mainly the M1 and M3 receptors which are being concentrated on. The aim of the experiment was to add a range of antagonists pig bladder tissue, and then recording the effect each had on the tissues contraction. The five antagonists used in the experiment were atropine, pirenzepine, methoctramine, 4-DAMP and oxybutynin. Each of the antagonists used are able to bind to muscarinic receptors, but they bind to different subtypes as they have differing affinities. Atropine is a non-selective antagonist, which acts via competitive inhibition of muscarinic acetylcholine receptors. It is a naturally occurring alkaloid which can be found in solanaceous plants, for example the deadly nightshade (Atropa belladonna). Atropine causes anti-cholinergic effects such as mydriasis, salivary inhibition, tachycardia, inhibition of GI motility and smooth muscle relaxation. It can be used clinically to treat anticholinesterase poisoning, bradycardia and GI hypermotility. Pirenzepine is a muscarinic receptor antagonist, and is slightly selective for the M1 sub-type. It is used clinically for the treatment of peptic ulcers, whereby it inhibits gastric acid secretion. Methoctramine is a slightly M2 selective antagonist. It has also been found to show selectivity for cardiac M2 muscarinic receptors, but to have low affinity for both vascular M2 and ganglionic M1 receptors. 4-DAMP is a slightly M3 selective antagonist, although it has only low affinity. There is no clinical use for 4-DAMP, it is mainly used in experiments for the analysis of muscarinic receptors. Oxybutynin is a non-selective muscarinic antagonist. It is used clinically to decrease muscle spasms of the bladder in patients suffering from frequent urination or urge incontinence. During the contractile experiment these antagonists will be used to determine which of the muscarinic receptors are present in the bladder, and which occur in the greatest amount. The same antagonists will then be used in the radioligand experiment, to compare each of their effects on brain tissue. Once both experiments are performed, the results can be used to compare the presence of muscarinic effects in the bladder and brain tissue. Materials and Methods Contractile response studies Strips of urinary detrusor were stored overnight at 4  °C in Krebs Ringer solution [composition (mM): NaCl (118); KCl (4.9), MgCl2 (1.2); KH2PO4 (1.2); D-glucose (12); NaHCO3 (25); CaCl2 (1.3); gassed with O2:CO2 (95:5)], as previously described (Lot and Wilson, 1994). On the morning of the experiment, tissue was removed from the refrigerator and allowed to equilibrate to room temperature. Thereafter, strips were mounted in an organ bath at 37  °C in Krebs Ringer solution. Contractility was monitored using isotonic transducers connected to CED 1502 amplifiers and recorded on a personal computer running Spike 2 software (CED, Cambs, UK). A steady baseline was then achieved for 20 minutes before 1ml 3M KCl was added to 50ml of Krebs solution (in water bath), to achieve a final concentration of 60mM. The tissue was then washed out three times once a maximal response was recorded, and this was then left for a further 20 minutes until a steady baseline was achieved once again. 10 dilutions containing varying concentrations of carbachol were then prepared in LP4 tubes, using 3-fold dilutions. A cumulative-concentration curve was created by adding the preparation containing the lowest concentration of carbachol to the organ bath first. After waiting for 7 minutes, the next preparation with a higher concentration was added. This process was repeated without washing out the tissue, until there was no further increase in tissue tone recorded. Once this part of the experiment was completed, the tissue was washed out 3 times with warm Krebs solution. This was followed by the addition of the putative antagonist and the tissue was left for 60 minutes. After achieving a steady baseline, a cumulative-concentration curve was created by carrying out the same process with increasing concentrations of carbachol as before; but this time in the presence of the putative antagonist. The results were printed off once the process was completed. Radioligand binding studies Radioligand binding to total particulate preparations from the pig was conducted essentially as previously described (Alexander et al., 1994). Briefly, tissue was homogenised in 10-30 volumes of 0.1 M phosphate buffer (pH 7.5) using an Ultra-Turrax homogeniser. After centrifugation at 30 000 g for 15 minutes at 4 °C, the supernatant layer was discarded. This homogenisation/centrifugation cycle was repeated twice more and the resulting pellet was re-suspended in 10 volumes. After storage at -20  °C, thawed tissue was incubated in a total volume of 500  µL 0.1 M phosphate buffer (pH 7.5), containing 0.25 nM [3H]-QNB for 30 minutes at 37  °C. Rapid filtration with repeated washing allowed isolation of bound radioligand, which was then estimated using liquid scintillation counting. A dilution curve was prepared using 10-fold dilutions once the drug was provided, this contained the highest concentration. 32 LP4 tubes were labelled 1-32 and these were placed in test tube racks. 50  µl aliquots of different concentrations of drug were then added to tubes 5-28, with each being made up to 500  µl by adding 450  µl of buffer. 50  µl of buffer was added to tubes 1-4, these acted as a control whilst atropine was added to the remained tubes 29-32. 400  µl of the radioligand was added to each of the tubes, with 50  µl of particulate preparation being added to the tubes in groups of 10 at 12 minute intervals. Once this process was completed, the tubes were incubated in a water bath at 37 °C for 30 minutes. The Whatman GF/B filters were placed in the 10-place manifold and were wet using the buffer solution. Ten of the tubes were then removed from the water bath, and 3ml of ice-cold buffer was added to each of them. They were filtered immediately after this process. Once two additions of 3ml of ice-cold buffer had taken place on each filter paper, they were washed. This was repeated for each of the LP4 tubes, once incubation in the water bath was halted on their removal. The filter papers were then placed into labelled scintillation vials, they were then analysed. Data analysis and statistical procedures There are equations which can be used to analyse the data collected in the experiment, once the information has been put into a concentration curve graph. The first equation used is the Gaddum equation: pKi = log (CR 1) log [Ant] In order to make use of this equation it is neccessary to work out the EC50, which is the effective concentration of drug required to give 50% of the maximum response. This EC50 value can be obtained from the concentration curve, as it is at 50% of the maximum response on the graph. The results collected from the graphs were Molar, these can be converted to  µM by multiplying the values by 106. These values can now be used to produce a concentration ratio, indicating the EC50 response with and without the presence of the antagonist. Graph 1 shows bladder tissue contractile responses to histamine in the presence of different concentrations of promethazine. The EC50 values recorded for histamine and promethazine were -6.5 and -5 respectively. By converting these Molar values to  µM by using the technique stated above, histamine 0.316  µM and promethazine 3.16  µM can be inputted into the Gaddum equation. The pKi value which is calculated in this equation is an indication of potency of the antagonist used, and a high pKi indicates a high affinity for the receptor. The pKi in this case was -8.5. As the radioligand was being carried out, calculations were made in order to work out the Kd and Bmax. The equation used in the radioligand binding experiment was the Cheng-Prusoff equation: IC50/Ki = 1 + [A]/Kd To work out the pKi, the same process as the contractile response experiment is used. Then the pIC50, the concentration of the antagonist which displaces 50% of the ligand, can be calculated. It is then necessary to work out the IC50 value to be used in the Cheng-Prusoff equation, this is achieved by -log of the pIC50 value. Finally, -log of the Ki obtained from the equation gives a pKi value of 8.2. Drugs, chemicals, reagents and other materials Porcine material (from pigs of the modern Hybrid white strain, either sex, approximately 50-70 kg) was obtained from an abattoir and transported rapidly to the laboratory on ice. [3H]-QNB (specific activity 1591 GBq mmole-1) was obtained from Amersham Pharmacia Biotech (Herts, UK), while muscarinic receptor ligands were all obtained from Sigma (Dorset, UK). All drug and molecular target nomenclature conforms to the British Journal of Pharmacologys Guide to Receptors and Channels (Alexander et al., 2008). Results Table 1. Contractile response results: Drug pEC50 Rmax Concentration Ratio pKi Atropine 4.5 131 20.9 9.1 Pirenzepine 4.3 109 42.6 7.4 Methoctramine 4.3 50.2 7.1 4-DAMP 4.6 139 37.9 9.2 Oxybutynin 4.3 210.5 8.1 Water 4.7 116 5.0 Table 1 shows the results obtained from the contractile response experiment, whereby the pig bladder tissue was exposed to five antagonists and the contractility of the tissue was measured. Table 2. Radioligand binding results: Brain Bladder Drug pKi SEM pKi SEM Atropine 9.8 0.1 9.8 0.1 Pirenzepine 7.7 0.2 8.0 0.6 Methoctramine 8.0 0.0 7.7 0.1 4-DAMP 9.2 0.0 8.4 0.1 Oxybutynin 7.4 0.0 7.8 0.0 Carbachol 4.8 0.1 4.3 0.0 Table 2 shows the results obtained from the radioligand experiment, which identified the different muscarinic receptors found in the brain and bladder tissue. Discussion and conclusions The conclusions that can be made from the results are that the main types of muscarinic receptor involved in the contraction of the bladder are the M1 and M3 receptor. Whereas, M1 and M2 muscarinic receptor subtypes occur in the brain. Therefore, an ideal drug for therapeutic treatment of urge incontinence and bladder dysfunction would be M3 selective. This would not have any adverse effects in the brain, as M3 receptors are not present in this part of the body. Bladder contractions occur due to activation of muscarinic receptors leading to an increase in intracellular calcium, which causes contraction of the smooth muscle. The results collected in the contractile response experiment were due to antagonism of M1 and M3 receptor subtypes. 4-DAMP recorded a pKi value of 9.2, a value which corresponded with the M3 subtype and was the highest of all the antagonists. This antagonist is M3 selective but also has affinity for the M1 muscarinic receptor; this may have caused its high pKi value to be due to binding at this muscarinic receptor subtype. Atropine recorded the second highest pKi, 9.1 .This was to be expected as it is a non-selective antagonist, with high affinity for each of the muscarinic receptor subtypes able to cause contraction of the bladder tissue. Oxybutynin recorded the third highest pKi value, 8.1. Oxybutynin has a slightly higher affinity for the M3 muscarinic receptor, therefore the pKi value is due to binding at this receptor subtype. Pirenzepine, being an M1 selective antagonist, would be expected to have a similarly high pKi to 4-DAMP. This was not the case as pirenzepine only recorded a pKi of 7.4, a value expected to be obtained from M3 selective antagonists. Methoctramine recorded a pKi value of 7.1, the lowest of all the antagonists. Although it is an M2 selective antagonist, the pKi value leads to the conclusion that contractile response is due to the presence of M1 or M3 receptors. The results obtained in the radioligand experiment revealed that mostly M1 and M2 muscarinic receptors occur in the brain. Methoctramine has low affinity at the M1 receptor, even so, the results recorded in the experiment showed the antagonist to have high affinity. The pKi range of the M2 receptor subtype for methoctramine is 7.8-8.3. Therefore, the recorded pKi value of 8.0 suggests the presence of M2 receptor subtypes in the brain. The pKi of 8.0 is quite far from the pKi range of methoctramine for the M3 receptor subtype, leading to the conclusion that there are a small number of M3 receptors in the brain. Atropine, perenzepine, 4-DAMP and oxybutynin antagonists are able to act at the M1 muscarinic receptor and each of these antagonists possess similar affinities for the receptor. Atropine (pKi 9.8) and oxybutynin (pKi 7.4) are both non-selective antagonists, so as in the contractile response will have fairly high affinities for any of the muscarinic receptor subtypes present in the brain. Perenzepine recorded a pKi value of 7.7; this failed to fall into any of the pKi ranges expected for the muscarinic receptors. The value was closest to the M1 subtype range (7.8-8.5). The SEM recorded was the highest of all the antagonists (0.2) concluding that some of the results may have been anomalous, with most of the pKi values falling within the M1 range. The Pki range of pirenzepine for the M3 receptor subtype is 6.7-7.1. The pKi recorded, much like that of methoctramine, was quite far from the M3 range. 4-DAMP recorded a high pKi of 9.2. This pKi value fell into the ranges for both the M1 and M3 muscarinic receptors, showing high affinity of the antagonist for both subtypes. In this experiment the pKi value recorded was with respect to the M1 receptor, not the M3 subtype. The non-selective muscarinic antagonist oxybutynin is the principle drug used to treat urge incontinence. This antagonistic drug possesses anticholinergic and antispasmolytic properties, which together act on the bladder to inhibit micturition. However, there are significant adverse effects associated with this choice of therapeutic treatment; such as dry mouth, constipation and blurred vision. These side effects highlight the non-selectivity of oxybutynin as each occurs due to antagonism at the M1 receptor. The radioligand binding experimental results show that oxybutynin has a pKi of 7.8 in the bladder, which is only slightly higher than the pKi of 7.4 recorded in the brain. These pKi values indicate that oxybutynin is slightly more selective towards the M3 receptor subtype present in the bladder. However, it is evident that the antagonist also has significant affinity towards the M1 and M2 receptor subtypes which are present in the brain. There were a few limitations encountered in both parts of the experiment. The contractile response experiment was carried out for a fairly short amount of time, more reliable results could be obtained by increasing the amount of time that the experiment is undertaken. As not all of the tissues used in the experiment were of the same source or size, the results obtained were inconsistent the responses recorded were of varying degrees. By ensuring every piece of tissue is the same size, more accurate and reliable could be obtained. Human error when collecting and interpreting the data in the experiment could have caused considerable variations in the results recorded. During the radioligand binding experiment complications arose due to contamination, with various external factors such as temperature and buffer strength affecting the results.

Behavioral Modeling Essay -- Ethics

Mental and healthcare providers need special awareness of professional boundary crossings and violations. There is a tendency towards encouraging those individuals to behave more empathically and less formally with their patients and clients makes such awareness increasingly important. Professional boundary ethics have been incorporated into the professional codes of many mental and healthcare providers all over the country, but it is important to have continuing education throughout the year (Al Sayyari, Hejaili, Jamal, Shamsi & Tamim, 2010). Mental and Healthcare providers must have specialized training to strike the right balance between rigidity and formality on one hand and undue laxity and informality in their approach on the other. This is the result in crossing boundaries and improper practice, with resulting harm to patients and clients. There is an important distinction than includes awareness of the distinction between boundary crossing and the boundary violations (Al Sayyari, Hejaili, Jamal, Shamsi & Tamim, 2010). Examples of boundary crossings would include paying the clients or patients bus fare or a bill; giving him or her a hug when a client or patient is distressed, and so on. Boundary violations, on the other hand, involve crossings that have the potential to prove harmful and exploitive to the client or patient. Boundary violations can involve a myriad of behaviors. Examples of these include- sexual abuse and harassment, sexual relationships, abuse of time or place of work, taking financial advantage of the client or patient, demanding gifts, coercing patients, misuse of fiduciary relationship, and improper with pharmaceutical companies (Al Sayyari, Hejaili, Jamal, Shamsi & Tamim, 2010). The worst type of ... ...para. 12). Last is called program climate, which includes an atmosphere conducive to learining, and competent informed, and ethical teachers (Vaquez, 1988). Works Cited Aamodt, M, (2010). Industrial/Organizational Psychology (6th Edition). Belmont, CA.: Cengage Learning. Browne, N.M., Giametro-Meyer, A. & Williamson, C. (2004). Practical Business Ethics for the Busy Manager. Upper Saddle River, New Jersey: Pearson Prentice Hall Bryant, S.E. & Fox, S.K. Behavioral Modeling Training and Generalization: Interaction of Learning Point Type and Number of Modeling Scenarios. The Psychological Record, Vol. 45, 1995. Hultman, K. E. (1986). Behavior Modeling for Results. Training & Development Journal, 40(12), 60. Mayer, S. J., & Russell, J. S. (1987). Behavior Modeling Training in Organizations: Concerns and Conclusions. Journal of Management, 13(1), 21.

Biometrics :: Biotechnology Science Essays

Biometrics Biometrics is a new term for many, but it is not a new idea. The idea of Biometrics first began with finger print analysis. Today, Biometrics has expanded to not only your fingerprints but also ear, face, facial thermogram, hand vein, hand geometry, iris, retina, signature and voice analysis. Technology has gone from science fiction to reality. This paper will include a brief description of each of the types of Biometrics and who is using them. The answer to "Who is using Biometrics?" may surprise you. In the United States over 150 schools are using a Biometrics system. This system allows the children to pay for cafeteria lunches. Over 200,000 students are participating in the Fingerprint Biometric system. The average system will cost any where from $4,000 to $10,000 to implement. How does it save you money? The answer is simply, you no longer need cashiers. All you need is a monitor. There is no longer cash to be accounted for, and children no longer have to bring money to school. Parents don’t have to worry how the money is being spent. The Fingerprint system is easy and results in quicker lines. Some major concerns for the parents are; 1.) How does the Fingerprint technology work? 2.) Can this technology be used in the police department? 3.) What about privacy issues? The technology being used in our school cannot be used in law enforcement. The fingerprint of your index finger is scanned, then transformed into a twenty-seven point grid, and a mathematical algorithm is the result. This is what the computer matches upnot your actual fingerprint. Ear Prints have had success for the Police in the United Kingdom. They have been using this technology to find missing persons and to identify unknown bodies. Ear prints are generally accepted as being unique, still it is hard to get a conviction if an ear print was left at the seen of a crime. Even though each ear is unique with its contour and lines; it has not been proven beyond a reasonable doubt that the ear print itself left behind is unique. There are fears of this new technology, because of its possible misuse and its accuracy. One of the greatest fears is that our justice system will go from innocent until proven guilty to guilty until proven innocent. This technology will bring great benefits until it fails, and then a tremendous amount of harm to even those who benefit from the technology.

Rural-Urban Linkages, Their Role in Sustainable Development

Although policy makers and the development community have widely used the phrase â€Å"rural development. The concept of rural development has changed significantly during the last 3 decades. Until the 1970s, rural development was synonymous with agricultural development and, hence, focused on increasing agricultural production. This focus seems to have been driven primarily by the interests of industrialization to extract surpluses from the agriculture sector to reinforce industrialization. With the focus on increasing agricultural production, the stated objective of most countries was to promote smallholder agriculture. Over time, this smallholder agriculture-centric concept of rural development underwent changes. By the early 1980s, according to Harris, the World Bank defined it as â€Å"†¦a strategy designed to improve the economic and social life of a specific group of people—the rural poor. Four major factors appear to have influenced the change: increased concerns about the persistent and deepening of rural poverty; changing views on the meaning of the concept of development itself; emergence of a more diversified rural economy in which rural non-farm enterprises play an increasingly important role; and increased recognition of the importance of reducing the non-income dimensions of poverty to achieve sustainable improvements in the socio economic well-being of the poor. The establishment of the Millennium Development Goals has significantly reinforce d the concerns about non income poverty. With the paradigm shifts in economic development from growth to broadly defined â€Å"development,† the concept of rural development has begun to be used in a broader sense. It is also more specific, as Harris noted â€Å"in the sense that it focuses (in its rhetoric and in principle) particularly on poverty and inequality. † In more recent years, increased concerns on the environmental aspects of economic growth have also influenced the changes. Today’s concept of rural development is fundamentally different from that used about 3 or 4 decades ago. The concept now encompasses â€Å"concerns that go well beyond improvements in growth, income, and output. The concerns include an assessment of changes in the quality of life, broadly defined to include improvement in health and nutrition, education, environmentally safe living conditions, and reduction in gender and income inequalities. â€Å"Today there seems to be a universal consensus that the ultimate objective of rural development is to improve the quality of life of rural people. As the concept of rural development changed so has the focus and approach to tackling and planning for rural development also change. Thus as already explained, today rural development is an integrated concept that that requires an integrated approach to development . thus the focus now is on sustainable development; hence an integrated sustainable rural development strategy is used to plan for rural development. However in order to successively design a strategy for integrated sustainable rural development, one must take into consideration rural-urban linkages because of the significant role it plays in sustainable rural development. Before proceeding with a discussion about the role that rural-urban linkages play in integrated rural sustainable development strategy, it may be necessary to define rural-urban linkages. In general, â€Å"rural-urban linkages† refers to the flow of (public and private) capital, people (migration, commuting) and goods and services (trade) between rural and urban areas. It is important to add to these three economic flows, the flow of ideas, innovation and information. These rural urban linkages could be expanded as; * The movement of people between rural and urban households many of which are of circular nature. These include temporary migration(as in seasonal moves ) and labour migration including weekly commuting; * The more permanent migration of people from rural to urban areas and vice versa. * The movement of people operating from a single rural urban household as in daily commuting or school trips, shopping and short term visits. * The movement of resources such as money and remittances, commodities and services. * There is also the more permanent type of linkages found mostly in infrastructure such as roads railway lines water and electricity telecommunication etc. Over the past few years, interest in the linkages between urban and rural areas has increased considerably. This is clear, for instance, from the activities of the United Nations. The Habitat Agenda, adopted at the second United Nations Conference on Human Settlements (Habitat II) in Istanbul in 1996, states that â€Å"policies and programmes for the sustainable development of rural areas that integrate rural regions into the national economy require strong local and national institutions for the lanning and management of human settlements that place emphasis on rural-urban linkages and treat villages and cities as two ends of a human settlements continuum. † (UNCHS, 1997: 93-94). however, Studies of rural urban linkages indicate that the nature of the linkages differs from one place to another and differs for different sectors in the same place. It is equally necessary to identify successful practices that promote local rural and urban development and alleviate poverty, using rural-urban linkages, and to build the capacity of rural and urban local governments to review, adapt and replicate such practices. The growing understanding and the pool of good practices should form the basis for capacity building of local governments. Among the above linkages the ,focus would be on the point 1 and 4 that’s the migration and the economic exchange of goods and services and their implication on rural development . this is because they are among the important rural urban linkages necessary for integrated sustainable rural development. These would be dis cussed shortly. To begin with the economic exchange between urban and rural areas can be beneficial or detrimental to either or both areas . hus with economic links between rural and urban areas, the extent to which economic development in the one area benefits or obstructs economic development in the other area. For instance an exclusive focus on rural areas would result in an under-investment in urban areas and this would limit the growth of the urban sector and its ability to absorb the rural labour surplus. Likewise an exclusive focus on urban development would produce similar results, because it would accelerate rural-urban migration and reduce food production per capita (Richardson, 1987: 210). Reardon (n. d. : 8-9) distinguishes three stages in the development of rural non-farm sector and of rural-urban linkages: †¢ During the first stage, rural non-farm activity tends to have a production or expenditure linkage with agriculture while farming directly employs a large share of the rural population. Rural non-farm activity tends to centre on the countryside itself, with little dependence on rural-urban links. Rural non-farm activities are mainly home-based and small-scale production of goods, mainly sold locally. During the first stage, agriculture tends to depend on local supplies of farm inputs and services and on local processing and distribution of farm products, usually carried out by small to medium-scale firms. †¢ A greater mix of situations characterizes the second stage. The mix includes activities based on linkages with agriculture as well as on other, separate activities (e. g. tourism, mining and services), although the latter did grow out of a historical rural non-farm sector based on linkages with agriculture. The share of rural population dependent on farming is lower than during the first phase. Rural-urban links as the basis for rural non-farm employment have a greater weight than in first stage with nascent sub-contracting of rural companies by urban or foreign businesses and a rapid rise in the labour force commuting between the countryside and rural towns and intermediate cities. †¢ The third stage shows an intensification of the characteristics that differentiate the second stage from the first stage. There is a greater weight of urban-rural links manifested by the greater importance of more advanced forms of business linkages, such as subcontracting arrangements and labour commuting. A number of other tendencies also characterize this stage: the expansion of subcontracting beyond light durables to medium durables. The great heterogeneity of the non-farm sector in rural areas implies that there is little scope for general, broad, policy prescriptions. This observation may well provide an important lesson for our thinking about the process of policy formulation. A wide variety of interventions may be required to promote the non-farm sector, each tailored to specific local conditions. Decentralized decision-making may be necessary: mechanisms should be devised whereby local information flows upwards so that the localized bottlenecks are relieved and specific niches can be exploited (Lanjouw, 1999: 9). From the above it can be realised that, rural-urban linkages can play an important role in economic development and poverty alleviation in urban and rural areas. However,it is important to recognize that the nature of the rural-urban linkages differs from one place to another and from one function to another. As Douglas (1998) has pointed out, a particular urban centre may play a crucial economic role for the surrounding rural areas in one respect, while the rural area may completely bypass that same urban centre and link directly to more distant urban centres and cities in other respects. It is, therefore, dangerous to generalize about the nature of rural-urban linkages and to base policy interventions on such generalizations. What is necessary is the recognition of (a) the existence a regional economy as a reality, rrespective of administrative boundaries, and (b) the need to develop knowledge about such regional (i. e. sub-national) economies (World Bank, 2000). The development of this knowledge should be demand-driven, as urban and rural local governments come to recognize their shared interests and constraints. The political impetus for this process of knowledge development may be t decentralization. In order to distribute economic and social opportunities equitably, the Government s hould strengthen grassroots economies that can provide sustainable incomes for the rural population. The Government should establish economic clusters that link rural and urban areas, and the cluster-based economic development should be consistent with the economic potentials, preferences and functions of each area. Another important rural urban linkage that has immense implication for today’s rural development is the rural urban migration. Thus the movement of people between rural and urban households . these include temporary migration and labour migration. Rural-urban migration reduces population pressure in the rural areas and, thereby, should improve economic conditions and reduce rural poverty. However, disparities between urban and rural areas in terms of income and employment and the availability of basic infrastructure and services persist. Urban areas offer more and better opportunities for socio-economic mobility of the poor and rural-urban migration, therefore, will continue. Labour migration could result in shortage of labour force for productivity in the rural areas which would intend result in low productivity and underdevelopment in the rural areas. Whereas the urban areas may not also be able to absorb the all the labour from the rural areas ,resulting in unemployment and increase in sanitation costs and government expenditure. it also increase population pressure in urban areas resulting in pressure on the few social amenities in urban centres. in this case, rural urban migration has more adverse effect on rural development. In addition to the above, Circular and temporary migration is already a common pattern in many countries, but working and housing conditions in the urban areas may not always be conducive to this form of migration. Housing is often an acute problem for temporary migrants who prefer to rent rather than to own housing, because they feel that their home is in the rural areas. Temporary migrants are sometimes not entitled to urban services and this makes their life in the urban areas more difficult than necessary. Local governments and private employers in the urban areas should accept temporary rural-urban migration as inevitable and perhaps even as desirable, and they may consider measures to facilitate such forms of rural-urban migration. For instance, Remittances are a crucial component of rural households’ incomes and a key element of the continued links between migrants and their home areas across all wealth groups. In northern Mali, migrants’ remittances have become probably the most important source of family cash, and are used for consumption and for the purchase of consumer goods such as radios and bicycles, but also for the purchase of agricultural inputs or for investment in livestock. In southeast Nigeria, it would be socially unacceptable for migrants not to send remittances and gifts: financial support to their parental households has greatly contributed to making young women’s migration socially acceptable. Most importantly, remittances and gifts ensure that migrants can maintain a foothold in the home area, and that they will be welcome upon their return. Gaile (1992: 134) argues that the problem is not urbanization as such, because the urban areas need to absorb the additional rural labour. The problem is that migrants have only a limited choice when migrating, because most local economic development occurs in one or a few large cities. He points out that the problem is really â€Å"under-urbanization†, i. e. the underdevelopment of the urban system. The major impediment to the working of the general market and the consequent development of a labour market is the undersupply of centres of sufficient minimal size to provide sites for market development. The above implies that in developing a strategy for sustainable rural development projects that encourages the bridging of gab between rural and urban areas should be considered. This would help reduce rural urban migration. Besides, major effort is required to ensure that the urban areas can absorb the growing urban population and that urbanization will not result in an urbanization of poverty. Small and medium-sized towns can play an important role in the urbanization process by absorbing rural-urban migrants. For instance Economic development in small towns can have a positive impact on the economy of the surrounding rural areas, if the increase in purchasing power results in the purchase of agricultural and non-agricultural products from the surrounding rural areas. This will obviously depend on the types of products produced, their quality and cost and their competitiveness compared to products from other parts of the country (and elsewhere). The development of the local urban economy may also lead to a reduction in rural-urban migration to the larger urban centres and the city and redirect migration flows to smaller urban centres. This in the long run led to sustainable development in both the rural and urban areas. Conclusion and Recommendations From the above discusions, it can be observe that there is growing interdependence of urban and rural areas that reduces the significance of the rural-urban distinction. The flow of people, capital, goods, services and ideas between urban and rural areas, made possible by improvements and cost reductions in communication and transport, is reinforcing the existing rural-urban linkages and more than ever conditions and developments in the urban areas have an impact on the rural areas and vice versa. Rural residents adopt urban lifestyles and occupations; small settlements require urban infrastructure and services; residents of rural areas commute between rural and urban areas; industries move to rural areas; urban waste pollutes natural resources in the rural areas; and agriculture in urban areas is becoming important for both economic and environmental reasons. It is, therefore, an anachronism that governments still design policies and programmes that are focused either on urban or on rural areas, but rarely on both. Rural and urban communities need to have an interest in each other’s conditions, and policy-makers need to consider these when formulating policies and programmes for sustainable rural development. Coordination of decision-making and cooperation between authorities of urban areas and their surrounding rural areas are critical to ensure that the development of urban areas and rural areas support each other. However, the continuing integration of rural and urban areas requires more than simply coordination and cooperation, it requires planning that incorporates rural and urban development. Such regional planning should not be an urban-centred exercise as it often has been in the past. Rural and urban areas need each other and each can benefit when the other’s needs are met. Backward linkages and forward linkages between agricultural production and industry and services can foster positive rural-urban interactions and a virtuous circle of development. However, policies that encourage such mutually reinforcing linkages need to overcome the traditional separation between rural and urban planners. They also need to avoid generalizations and be grounded in the specifics of the regional context (Tacoli, 1998: 13).

Locke on Language Essay

John Locke (1632-1704) is a great influential British philosopher, reputed by many as the first of the great English empiricists. He offered a comprehensive philosophy of language as well, which was the first of its kind in modern philosophy. In line with Descartes, he pushed reason to the forefront as a tool of philosophical enquiry and opposed authoritarianism and blind acceptance of dictates of religion or superstitions. Locke’s masterpiece, An Essay Concerning Human Understanding, concerns itself with determining the limits of human understanding and the legitimacy of knowledge claims. Specifically, Book III of the work investigates into language and its importance in the process of knowledge and epistemological enquiries. Let me brief the main aspects of his approach to language and the context from which it evolves out. Body of the Essay (Lockean Enquiry into Language) In the four Books of the Essay, Locke considers the sources and nature of human knowledge and as a part of it he takes up a study of language. (An Essay Concerning Human Understanding, Locke, 1. 1. 7. , p. 47). Against Descartes, he claimed, that mind has no innate ideas (primary notions or inborn ideas). Human mind is a tabula rasa (clear slate) and experiences write on it. In holding this view he subscribes to the axiom of empiricism that ‘there is nothing in the intellect that was not previously in the senses’. Ideas are but materials, out of which, knowledge is constructed. Neither speculative or innate moral principles, nor ideas, such as God, identity, etc. , are there in the mind of the new-born. ‘Children and the idiots prove it’, Locke says. His theory of substratum and substance, and the distinction he makes between primary and secondary qualities are all someway connected to his theory of language. The distinction between real essences and nominal essences, which he makes, stems from his theories of substance and qualities. It seems Locke holds some version of the representational theory of perception, though some scholars dispute it. Locke is not at all skeptic about substances as did Hume. Since Berkeley, Locke’s theory of the substratum or substance has been attacked as incoherent. Since we have no such experience of such an entity there is no way to derive such an idea from experience, his critics argue. (cf. I. IV. 18. p 95) The real essence of a material thing is its atomic constitution. The atomic constitution is the causal basis of all the observable properties of the thing. If the real essences were known all the observable properties could be deduced from it. These real essences are quite unknown to us according to Locke. Ayer interprets: ‘substance in general’ means whatever it is that supports qualities, while the real essence means ‘the particular atomic constitution lying behind observable qualities. Ayer treats the unknown substratum as the same as real essence. This interpretation eliminates the need to explain particulars without properties. But it is to be accepted that such reductionism lacks textual support from Locke and it conflicts some of Locke’s own positions according to some critics. A theory of meaning (semantic theory) is central to any philosophical account of language Locke also develops one when he claims that our words (general terms) refer to our (abstract) ideas. Abstract ideas and classification are of central importance to Locke’s discussion of language. Words that stand for ideas can be distinguished as ideas of substances, simple modes, mixed modes, relations etc. Not all words are ideas, for example, particles that relate. In his analysis of language, Locke gives more attention to nouns than to verbs (II. 7. 1. p 471). Though Locke’s main semantic theory claimed that â€Å"Words in their primary or immediate signification signify nothing but the ideas in the mind of him that uses them†, it was vehemently criticized as a classic blunder in semantic theory. For J. S. Mill, Locke seems not distinguishing the meaning of the word from its reference. But as Norman Kretzmann rightly points out Locke distinguishes between meaning and reference (Tipton, 1977, pp. 123-140). In Locke’s discussion on substances, he says, physical substances are atoms and things made up of atoms. But we have no experience of the atomic structure of horses and tables. Horses and tables are known through secondary qualities such as color, taste, smell etc and primary qualities such as shape and extension. Hence he held that real essence cannot give meaning of names. Ordinary people are the chief makers of language, he believed. Conclusion Locke brought in a tradition in language theory that influenced James Campbell and I. A. Richards, rhetoricians like Edward P. J. Corbett, Condillac, Saussure and structuralists like Claude Levi-Strauss. Linguistic philosophy (logical positivism, logical atomism and so on) in 20th century had something to respond to Locke if not to receive from him. However, I wouldn’t reckon Locke as a linguist than an empiricist. References Locke, John (1995) An Essay Concerning Human Understanding. Aemherst, New York: Prometheus Books. Kretzmann, Norman (1977) â€Å"The Main Thesis of Locke’s Semantic Theory†. in Locke on Human Understanding,(ed) I. C. Tipton. pp. 123-140.